The First Publication with a Separate Printed Title Page (1463)

With his edition of Pope Pius II's Bulla Cruciatae contra Turcos printer Peter Schöffer issued the first publication with a separate printed title page. 

It is thought that this title page was an experiment, as "the Aschaffenburg copy has a title-page in Psalter type; the Paris copy has a woodcut title; the Musée Condé copy has a title in MS" (ISTC no. ip00655750 citing two copies in France, three in Germany and one in Holland).

• The separate title page did not begin to come into widespread use in printed books until the end of the 15th century.

Smith, The Title-Page, its Early Development 1460-1510 (2000) 38-40.