Jeremy Norman’sHistoryofInformation.com Exploring the History of Information and Media through Timelines
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A: London, England, United Kingdom
Published by The Times in 1833; the machine was invented by Applegath & Cowper in 1827 and made operational in 1828.
In 1827 Edward Cowper and his brother-in-law Augustus Applegath invented the four-cylinder printing machine. This could print between 4200 and 5000 copies per hour. The illustration from The Times' Printing in the Twentieth Century (1930) shows the machine built for The Times of London and operational in 1828.
According to Moran, Printing Presses, p. 130, The Times was still using this machine in 1843.